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Cushings and breast cancer

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A new case report in the Journal of the Endocrine Society documents how a patient's use of a common biotin supplement, also known as vitamin B7, caused her to have clinically misleading test results, which prompted numerous consultations and unnecessary radiographic and laboratory testing. The patient in the case report took a mcg dose of biotin daily. They are marketed as being good for healthy hair, skin and nails, but there is no scientific evidence to support this claim. In this patient's case, "The negative clinical impact included weeks of psychological distress concerning the possibilities of hypercortisolemia or a testosterone-producing tumor. Most significantly, these abnormal test results nearly resulted in an unnecessary invasive procedure for a complex patient with a hypercoagulable state," the case report says.
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A review and meta-analysis of red and processed meat consumption and breast cancer

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Cushing's syndrome: Causes, symptoms, types, and diagnosis

Back to Health A to Z. Cushing's syndrome is a condition caused by having too much of a hormone called cortisol in your body. It can be serious if it's not treated. Cushing's syndrome is uncommon. It mostly affects people who have been taking steroid medicine , especially steroid tablets, for a long time. Steroids contain a man-made version of cortisol.
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New Medication Approaches to Treat Cushing's Syndrome

Bexarotene sold under the brand name Targretin is approved to treat cutaneous T-cell lymphoma. They also selected lapatinib brand name Tykerb , approved to treat advanced forms of hormone-driven breast cancer , due to its ability to block the PI3K-AKT pathway , which controls cancer cell growth and survival. By inhibiting this signaling pathway, lapatinib can potentially prevent tumor cells in the pituitary gland from expanding. Vote count: 1.
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Cushing syndrome develops when an individual is chronically exposed to high levels of glucocorticoids, such as cortisol. In a minority of patients about percent high levels of ACTH are secreted by an ectopic extrapituitary neuroendocrine tumor — a tumor that occurs outside the pituitary gland. Most cases of extrapituatary tumors include small-cell lung cancer SCLC and bronchial carcinoid tumors.
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