Since the late s, scientists have explored how to produce sperm where all of the chromosomes come from a female donor. Creating female sperm was first raised as a possibility in a patent filed in  by injecting a woman's cells into a man's testicles, though the patent focused mostly on injecting altered male cells into a man's testes to correct genetic diseases. In , Japanese scientists partially confirmed such techniques by creating chicken female sperm in a similar manner. It is therefore concluded that most of the W-bearing PGC could not differentiate into spermatozoa because of restricted spermatogenesis. One potential roadblock to injecting a woman's cells into a man's testicles is that the man's immune system might attack and destroy the woman's cells.
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Klinefelter syndrome KS , also known as 47,XXY is the set of symptoms that result from two or more X chromosomes in males. Klinefelter syndrome occurs randomly. While no cure is known, a number of treatments may help. Klinefelter syndrome is one of the most common chromosomal disorders , occurring in one to two per 1, live male births. The primary features are infertility and small poorly functioning testicles.
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A male cannot reproduce sexually without access to at least one ovum from a female, but some organisms can reproduce both sexually and asexually. Not all species share a common sex-determination system. In most animals , including humans , sex is determined genetically ; however, species such as Cymothoa exigua change sex depending on the number of females present in the vicinity.